Pre-operative endocrine therapy for postmenopausal women: When and why?
نویسندگان
چکیده
منابع مشابه
Pre-operative Endocrine Therapy
Purpose of Review Pre-operative endocrine therapy can be used to down-stage large or locally advanced breast cancers in ER+ disease. In the last four decades, it has evolved from a treatment perceived as an alternative to surgery for those too unfit to undergo surgery or chemotherapy, to the present day where it is a valuable and valid option in the treatment of postmenopausal women with ER-ric...
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The relationship between hidradenitis suppurativa (HS) and hyperandrogenism is largely based on the finding of an increased free androgen index due to a low sex hormone binding globulin (SHBG). As SHBG is now believed to be regulated by factors that influence body weight, and previous studies were not controlled for body weight, we have re-evaluated the androgen status of female patients with H...
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Results from multiple clinical trials involving aromatase inhibitors have added to the knowledge base relating to endocrine therapy of postmenopausal women with hormone receptor-positive early breast cancer. In the extended adjuvant setting, data from the Austrian Breast and Colorectal Cancer Study Group 6a trial showed an advantage for anastrozole following 5 years of tamoxifen treatment, cons...
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The majority of invasive breast cancer patients present with hormone receptor-positive disease, and modulation of estrogen receptor (ER) activation is an essential component of systemic adjuvant therapy for these women. While tamoxifen has traditionally been the primary adjuvant endocrine therapy for all ER-positive women, recent trials evaluating the use of aromatase inhibitors (AIs) have chal...
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†Author for correspondence 1Clinical Trial Coordinator, Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, The University of Birmingham, B15 2TT, UK Tel: +44 121 414 3797 Fax: +44 121 414 3700 [email protected] 2Senior Lecturer in Medical Oncology, Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, The University of Birmingham, B15 2TT, UK Tel: +44 121...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2001
ISSN: 0923-7534
DOI: 10.1023/a:1013102303360